Capillary morphogenesis protein 2
WebCapillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo Shihui Liu1, Devorah Crown, Sharmina Miller-Randolph, Mahtab Moayeri, …
Capillary morphogenesis protein 2
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WebDetects human CMG‑2/ANTXR2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 20% cross-reactivity with recombinant mouse CMG-2 is observed. Source Polyclonal Goat IgG Purification Antigen Affinity-purified Immunogen Mouse myeloma cell line NS0-derived recombinant human CMG‑2/ANTXR2 isoform 1 … WebMar 21, 2024 · intraflagellar transport protein 74 homolog, capillary morphogenesis gene 1 protein, capillary morphogenesis protein 1, coiled-coil domain containing 2, coiled-coil domain-containing protein 2, intraflagellar transport 74 homolog. GeneRIFs: Gene References Into Functions.
WebJul 28, 2009 · Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo Shihui Liu, Devorah Crown, Sharmina Miller-Randolph, +4, and Stephen H. Leppla Authors Info & Affiliations Edited by Stanley N. Cohen, Stanford University School of Medicine, Stanford, CA, and approved June 8, 2009 July 28, 2009 WebTwo distinct cellular receptors for anthrax toxin have been identified and are designated capillary morphogenesis protein 2 (CMG2) and anthrax toxin receptor/tumor endothelial marker 8 (ATR/TEM8). The molecular details of the toxin-receptor interactions have been revealed through crystallographic, biochemical and genetic studies.
WebDec 5, 2016 · Here, we discovered that EphA2, a member of the large family of Ephrin receptor tyrosine kinases, is a functional signaling receptor for progranulin. Recombinant progranulin bound with high affinity to EphA2 in both solid phase and solution. WebJun 27, 2024 · It is hypothesized that disruption of this membrane protein causes accumulation of hyaline materials and tissue damage/malfunction in multiple organs. 7 Owing to its rarity and associated rapid clinical deterioration, timely diagnosis of ISH is difficult and, as a result, it may be underdiagnosed.
WebDec 27, 2012 · DOI: 10.3390/toxins5010001. Abstract. Tumor endothelium marker-8 (TEM8) and capillary morphogenesis protein-2 (CMG2) are the two well-characterized anthrax …
WebApr 16, 2003 · However, in this report we identify the human capillary morphogenesis protein 2 (CMG2) as a second anthrax toxin receptor. CMG2 is the protein most similar … honda finance payoff address overnightWebJan 14, 2013 · CMG2 is a transmembrane protein that is induced during capillary morphogenesis and that binds laminin and collagen IV via a VWFA domain. The … honda finance optionsWebOct 18, 2016 · Infanile systemic hyalinosis (ISH) is caused by mutations in the gene encoding capillary morphogenesis protein-2 ( CMG2, or ANTXR2; 608041) on chromosome 4q21.21 [ 1 – 3 ]. The disorder is allelic with juvenile hyaline fibromatosis, which has milder clinical features. honda finance overnight addressWebPA binds to either of two receptors, capillary morphogenesis protein-2 (CMG-2) or tumor endothelial marker-8 (TEM-8), which triggers the binding and cytoplasmic translocation of LF and EF. However, the distribution of functional TEM-8 and CMG-2 receptors during anthrax toxin intoxication in animals has not been fully elucidated. history of chiltern raWebThe ANTXR2 protein is involved in the formation of tiny blood vessels (capillaries). It may also be important for maintaining the structure of basement membranes, which are thin, … history of chili pepperWebThis condition is due to mutations in the anthrax toxin receptor-2 ( ANTXR2) gene. This gene is also known as capillary morphogenesis protein-2. This gene is located on the long arm of chromosome 4 (4q21.21). Management [ edit] There is no presently known curative treatment for this condition. [citation needed] Management is supportive history of childress texasWebThere are two known homologous receptors, which bind to PA83, called tumor endothelium marker-8 ( TEM8) and capillary morphogenesis protein 2 ( CMG2 ). [3] Then a 20 kDa fragment (PA20) is cleaved off … honda finance payment credit card