Circrhot1
WebFigure 1: Characterization of circRHOT1 in BC. (a) circRHOT1 level in BC cell lines detected by qRT-PCR. (b, c) circRHOT1 and RHOT1 mRNA expression measured by qRT-PCR in HT-1376 (b) and HTB9 (c) cells treated with RNase R … WebDec 9, 2024 · Novel therapeutic strategies for BC clinical intervention are therefore urgently needed now more than ever. circRHOT1 is a newly identified circRNA that plays a crucial role in multiple types of tumorigeneses. However, it remains unclear whether circRHOT1 plays a functional role in BC progression.
Circrhot1
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WebFigure 1. CircRHOT1 is enhanced in clinical NSCLC samples and NSCLC cell lines. (A) The expression of circRHOT1 was analyzed by qPCR in clinical NSCLC tissues (n = 60) and peri-tumor tissues (n = 60).(B) The expression of circRHOT1 was measured by qPCR in the indicated cells.(C) The back-spliced and canonical forms of RHOT1 expression was … WebCircRHOT1 enhances CCND1 expression by sponging miR-142-5p to inhibit chondrocyte autophagy and promote chondrocyte proliferation in OA [143]. Circ_0005526 promotes IL-1β-induced chondrocyte ...
WebCircRHOT1 represses autophagy and in the OA rat model. (a)–(e) The OA rat model was constructed by receiving ACLT, and the OA rats were treated with circRHOT1 shRNA. (a) The expression of... WebHCC cells were infected with CRISPR/Cas Lentivirus containging circRHOT1-sgRNAs. circRHOT1-deficient HCC cells were screened out. Growth protocol HCC cells were cultured in DMEM medium supplemented with 20 % FBS, 2 mM glutamine, 1 mM pyruvate, 10 mM HEPES, 100 units/mL penicillin/streptomycin, 0.1 mg/mL gentamicin, and 2 g/L …
WebDownload scientific diagram circRHOT1 knockout suppresses HCC cell proliferation, migration and invasion but promotes apoptosis. a The expression of circRHOT1 was analyzed by qRT-PCR in ... WebApr 4, 2024 · circRHOT1 inhibits HCC development and progression via recruiting TIP60 to initiate NR2F6 expression, indicating that circRHOT1 and NR2F6 may be potential biomarkers for HCC prognosis. NR2F6 is identified as a direct target of miR-142-3p, which was negatively correlated with miR-142-3p expression.
WebMar 3, 2024 · The circRHOT1 knockdown notably increased the levels of reactive oxygen species (ROS), iron, and Fe2+in breast cancer cells. Mechanically, circRHOT1 was able to sponge microRNA-106a-5p (miR-106a-5p) and inhibited ferroptosis by down-regulating miR-106a-5p in breast cancer cells. how does my body burn fatWebThe study by Wang et al 34 showed that circRHOT1 is upregulated in HCC tissues and is associated with a poor prognosis. In-body and out-of-body studies have shown that circRHOT1 triggers the expression of NR2F6 to promote tumor growth and metastasis. The above research shows that circRNA participates in various biological behaviors of HCC, … how does my body use lipidsWebJun 11, 2024 · Circular RNA circRHOT1 promotes hepatocellular carcinoma progression by initiation of NR2F6 expression Mol. Canc. (2024) D.H. Bach et al. Circular RNAs in cancer Mol. Ther. Nucleic Acids (2024) Z. Peng The long noncoding RNA LINC00312 induces lung adenocarcinoma migration and vasculogenic mimicry through directly binding YBX1 Mol. … how does my chart healthcare system worksWebNoteworthy, circRNAs mainly function through sponging microRNA (miRNA) or directly with targeted proteins. 7 For example, circRHOT1 epigenetically regulates lung cancer progression via recruiting KAT5. 15 Importantly, the previous studies have identified the critical function of circRNAs in the regulation of MI progression, including circTtc3 ... how does my cat see meWebFigure 1. CircRHOT1 is enhanced in clinical NSCLC samples and NSCLC cell lines. (A) The expression of circRHOT1 was analyzed by qPCR in clinical NSCLC tissues (n = 60) and … how does my cat ask for helpWebNational Center for Biotechnology Information how does my employer pay my ex wife alimonyWebAug 18, 2024 · CircRHOT1 is involved in the modulation of cell invasion, apoptosis, and proliferation by targeting miR-125a-3p in pancreatic cancer cells [11]. CircRHOT1 is increased and contributes to cell invasion and proliferation of pancreatic cancer cells [12]. Our data showed that circRHOT1 was elevated in clinical NSCLC samples and NSCLC … how does my charity rate