Ctgf tumor

Author: lbor

August undefined, 2024

WebJun 16, 2024 · FibroGen's pamrevlumab is a first-in-class antibody that inhibits the activity of connective tissue growth factor (CTGF), which, in cancer, is characterized by promotion of tumor growth. WebJun 15, 2012 · Therefore, we investigated whether CTGF modulates metabolism in the tumor microenvironment. For this purpose, CTGF was overexpressed in normal human fibroblasts or MDA-MB-231 breast cancer cells. Overexpression of CTGF induces HIF-1α-dependent metabolic alterations, with the induction of autophagy/mitophagy, …

Connective tissue growth factor in tumor pathogenesis

WebJul 8, 2013 · Accordingly, we investigated the function of connective tissue growth factor (CTGF), a protein known to be important in stromal formation. CTGF is a pleiotropic and cysteine-rich matricellular protein that is abundant in many solid malignancies including pancreas, breast, esophageal, glioblastoma, and hepatocellular carcinoma ( 18 – 23 ). WebSep 4, 2024 · Connective tissue growth factor (CTGF) is a matricellular protein related to hepatic fibrosis. This study aims to clarify the roles of CTGF in hepatocellular carcinoma (HCC), which usually develops from fibrotic liver. CTGF was overexpressed in 93 human HCC compared with nontumorous tissues, primarily in tumor cells. cursus cryptocurrency

CTGF Mediates Tumor–Stroma Interactions between Hepatoma …

WebElevated CTGF expression has been detected in many tumor types [5,17] where it has been identified as an invasion-specific gene [18] and is highly expressed within the neoplastic epithelium of PDAC [9]. Wenger et al. showed 59-fold enhancement of CTGF expression in 15 out of 19 samples of pancreatic tumors, compared with only 4.5-fold WebIn pancreatic cancer, CTGF is a critical regulator of tumor growth, and CTGF-specific antibody attenuates tumor growth and metastases in vivo [7, 8]. On the other hand, increased CTGF expression has been correlated with improved prognosis in chondrosarcoma patients and in patients with lung cancer [ 9 , 10 ]. WebSep 9, 2015 · High expression of CTGF in breast tumor epithelial component correlates with poor clinical prognosis and outcomes. The interaction between tumor and stromal cells and their signaling output mould the microenvironment to support tumorigenesis and metastasis [].In this context, cytokines, chemokines, as well as growth, angiogenesis and … chase bank arapaho garland tx

CTGF is a central mediator of tissue remodeling and …

Targeting of CCN2 suppresses tumor progression and improves …

WebCTGF expression has been tied in with tumor growth, invasion, and metastasis. It shows aberrant expression in many forms of cancer, such as prostate, breast, and esophageal … WebMar 10, 2024 · CTGF is overexpressed in triple-negative breast cancer. In a publicly available gene expression database, the Cancer Cell Line Encyclopedia portal, we … cursus cv onderhoudWebApr 20, 2016 · Breast cancer is the most common cancer in women worldwide, and approximately 90% of breast cancer deaths are the result of metastasis. Metastasis is the process by which tumor cells detach from a primary tumor and migrate to nearby blood vessels or the lymph system, and are thereby able to spread to other organs in the host … chase bank arcadia ca

"WebOct 29, 2024 · Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved in different biological processes, such as cell proliferation, angiogenesis, and wound healing, as well as multiple … " - Ctgf tumor

Ctgf tumor

Reduced CTGF Expression Promotes Cell Growth, Migration, and

WebFeb 28, 2024 · Results . AuNPs were able to decrease the density of colorectal cancer associated fibroblasts (CAFs), to reduce the production of tumor stromal collagen I, and to diminish the expression of profibrotic signals, including CTGF, TGF-β1 as well as VEGF in vivo and vitro via Akt signaling pathway. WebAug 9, 2010 · MUC1 increases CTGF/CCN2 expression in pancreatic tumors cells. The MUC1.CT conducts signals from the cell surface by associating with and modifying the activity of transcriptional activators and ...

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WebAug 8, 2024 · Lai, D., Ho, K. C., Hao, Y. & Yang, X. Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF. Cancer Res ... WebJul 12, 2014 · Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that CCN2/CTGF mediates cell adhesion, aggregation and migration in a large variety of cell types, including vascular endothelial cells, fibroblasts, epithelial cells, aortic smooth …

WebJul 18, 2024 · Dynamic interaction between prostate cancer and the bone microenvironment is a major contributor to metastasis of prostate cancer to bone. In this study, we utilized an in vitro co-culture model of PC3 prostate cancer cells and osteoblasts followed by microarray based gene expression profiling to identify previously unrecognized prostate … WebAug 6, 2024 · Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other growth factors and promotes kidney fibrosis. ... cancer, and infections. Glomerulonephritis is a common cause of end-stage renal failure. Severe and prolonged inflammation can …

WebSep 1, 2024 · Connective tissue growth factor (CTGF) is a matricellular protein related to hepatic fibrosis. This study aims to clarify the roles of CTGF in hepatocellular carcinoma … WebMar 1, 2015 · Upon TGFβ1 stimulation, low-CTGF HCC cells formed tumors with a high stromal content and CTGF expression, which was inhibited by treatment with LY2109761. Blocking TGFβ signaling with LY2109761 or galunisertib inhibited CTGF synthesis and release by HCC cells and reduced tumor stromal content by inhibiting fibroblastic cell …

WebConnective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell proliferation, differentiation, adhesion and angiogenesis, as well as multiple pathologies, such as tumor development and tissue fibrosis.

WebSep 12, 2024 · INTRODUCTION. Urothelial bladder cancer (UBC) is a common urinary malignancy. In 2012, about 429,800 new cases and 165,100 deaths arising from UBC occur worldwide [].In the United States, UBC is estimated that to be the second most frequent genitourinary tract cancer and the fourth most common cancer in male in 2024 [].At … cursus cybersecurityWebSep 17, 2024 · Elevated expression of markers of gingival fibrosis (particularly CTGF), markers of epithelial–mesenchymal transition (EMT), periostin, and enzymes of the lysyl oxidase family have been documented in DIGO. ... phenotype and develop the mesenchymal phenotype during embryonic development, 12 fibrogenesis, 13 wound … curs usd 31.12.2020WebJun 6, 2012 · Key roles for connective tissue growth factor (CTGF/CCN2) are demonstrated in the wound repair process where it promotes myofibroblast differentiation and angiogenesis. Similar mechanisms are … curs usd bnr august 2022WebWe examined in detail the molecular mechanisms of MUC1.CT signaling that induces the expression of connective tissue growth factor (CTGF/CCN2), a potent mediator of ECM remodeling and angiogenesis. We demonstrate a robust induction of CTGF synthesis and secretion in response to serum factors that is enabled only when MUC1 is highly expressed. chase bank archerWebSep 15, 2024 · Malignant mesothelioma (MM) is an aggressive mesothelial cell cancer type linked mainly to asbestos inhalation. MM characterizes by rapid progression and resistance to standard therapeutic modalities such as surgery, chemotherapy, and radiotherapy. Our previous studies have suggested that tumor cell-derived connective tissue growth … curs usd 31.12.2021WebMay 10, 2024 · Our findings suggest that CTGF is a marker for medulloblastoma independent of molecular subgroups and its transcriptional program is active at the … chase bank arcadia flWebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast activation protein (FAP) and the connective tissue growth factor (CTGF) can function in tumor-associated stromal cells but are practically inactive in normal adult cells. Accordingly, the … cursus data-analyse