WebFollistatin (FST), as a single-chain glycosylated protein, has two major isoforms, FST288 and FST315. The FST315 isoform is the predominant form whilst the FST288 variant … WebNov 25, 2024 · FST is a single-chain glycosylated (N-glycosylation sites on asparagines 124 and 288) protein whose primary function consists in binding and neutralizing some members of the transforming growth factor-β (TGF-β) superfamily such as activin and bone morphogenic proteins. FST was originally identified in porcine ovarian follicular fluid and ...
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WebIntroduction. Follistatin (Fst) binds several members of the transforming growth factor-β superfamily including activins and Mst to neutralize their biological activities. 1–3 Several genetic studies have demonstrated an essential role for Fst in skeletal muscle development 3–6; however, the role of Fst in other metabolic tissues is poorly understood. WebELISA was used to quantify FST induction in patient samples and in vitro in response to chemotherapy. Results: We found that NFATC4 upregulates follistatin (FST) mRNA and protein expression predominantly in quiescent cells and FST is further upregulated following chemotherapy treatment. FST acts in at least a paracrine manner to induce a p-ATF2 ... giants spring training games
Recombinant Human Follistatin 288 (FS-288) Protein
WebJun 13, 2024 · Follistatin (FST) regulates TGFβ family signaling by selectively binding TGFβ family ligands and sequestering them. In humans, FST is up-regulated in the decidua during early pregnancy, and women with recurrent miscarriage have lower endometrial expression of FST during the luteal phase. WebSep 27, 2024 · Follistatin may play some roles in the interactions between muscle and bone metabolism in response to gravity change. Fst promotes brown adipocyte characteristics in both white adipose tissue and brown adipose tissue depots in vivo through distinct mechanisms. WebDec 19, 2024 · Follistatin is an autocrine glycoprotein that is expressed in nearly all tissues of higher animals. What does follistatin 344 do? Follistatin 344 (FST-344) Follistatin (FST) is a secreted glycoprotein … giants spring training packages