WebThe endothelium lines the luminal surface of the arterial wall and is in direct contact with blood flow. The pulsatile shear stress (PS) at straight parts of arteries maintains endothelial homeostasis, whereas oscillatory shear stress (OS) at bifurcations and curvatures impairs endothelial function. WebApr 11, 2024 · To systematically dissect the transcriptomic differences between homeostasis and chronic dry skin at the single-cell level, we carried out scRNA-seq on two biological mixed samples from each group, and each mixed sample contained three mice (Fig. 1 A).After quality control, we obtained 18,578 cells in the AEW groups and 24,160 …
KLF2+ stemness maintains human mesenchymal stem …
WebApr 30, 2024 · Expression of KLF2 by endothelial cells is known to exert protective effects against atherosclerosis, however OSS greatly reduces expression of KLF2 at both the mRNA and protein levels. To determine whether GPR30 plays a role in OSS-induced downregulation of KLF2, HAECs were exposed to OSS (± 5 dyn/cm 2 ) in the presence or absence of 5 and … WebJan 24, 2024 · The role of KLF2 (Kruppel like factor 2) in ECs (endothelial cells) dysfunction and homeostasis. KLF2 is the major MSTF regulated by shear stress: down-regulated by … hallmark ornaments value guide download
The zinc finger transcription factor, KLF2, protects against ... - Nature
WebJul 28, 2024 · Endothelial cells (ECs) are professional mechanosensing cells that constantly perceive and respond to the hemodynamic forces generated by blood flow. 1 The hemodynamic forces play a critical role in the development and geometric distribution of atherosclerosis, 2 a leading cause of death in patients with stroke and myocardial … WebIn the human body, KLFs are mainly involved in various physiological processes such as enhancing immune response, maintaining the normal function of vascular endothelium, … WebOct 30, 2014 · KLF2 Controls Endothelial Cell Glycolysis and Angiogenic Phenotype Partly via PFKFB3 Inhibition PFKFB3 was recently shown to be an important regulator of endothelial cell glycolysis, 9 and we therefore hypothesized that inhibition of PFKFB3 could be the underlying mechanism by which KLF2 reduces endothelial cell glycolysis. hallmark ornaments thimble series