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Klf2 endothelial cell

WebThe endothelium lines the luminal surface of the arterial wall and is in direct contact with blood flow. The pulsatile shear stress (PS) at straight parts of arteries maintains endothelial homeostasis, whereas oscillatory shear stress (OS) at bifurcations and curvatures impairs endothelial function. WebApr 11, 2024 · To systematically dissect the transcriptomic differences between homeostasis and chronic dry skin at the single-cell level, we carried out scRNA-seq on two biological mixed samples from each group, and each mixed sample contained three mice (Fig. 1 A).After quality control, we obtained 18,578 cells in the AEW groups and 24,160 …

KLF2+ stemness maintains human mesenchymal stem …

WebApr 30, 2024 · Expression of KLF2 by endothelial cells is known to exert protective effects against atherosclerosis, however OSS greatly reduces expression of KLF2 at both the mRNA and protein levels. To determine whether GPR30 plays a role in OSS-induced downregulation of KLF2, HAECs were exposed to OSS (± 5 dyn/cm 2 ) in the presence or absence of 5 and … WebJan 24, 2024 · The role of KLF2 (Kruppel like factor 2) in ECs (endothelial cells) dysfunction and homeostasis. KLF2 is the major MSTF regulated by shear stress: down-regulated by … hallmark ornaments value guide download https://daisyscentscandles.com

The zinc finger transcription factor, KLF2, protects against ... - Nature

WebJul 28, 2024 · Endothelial cells (ECs) are professional mechanosensing cells that constantly perceive and respond to the hemodynamic forces generated by blood flow. 1 The hemodynamic forces play a critical role in the development and geometric distribution of atherosclerosis, 2 a leading cause of death in patients with stroke and myocardial … WebIn the human body, KLFs are mainly involved in various physiological processes such as enhancing immune response, maintaining the normal function of vascular endothelium, … WebOct 30, 2014 · KLF2 Controls Endothelial Cell Glycolysis and Angiogenic Phenotype Partly via PFKFB3 Inhibition PFKFB3 was recently shown to be an important regulator of endothelial cell glycolysis, 9 and we therefore hypothesized that inhibition of PFKFB3 could be the underlying mechanism by which KLF2 reduces endothelial cell glycolysis. hallmark ornaments thimble series

KLF2 - Wikipedia

Category:Endothelial Cell Dysfunction and the Pathobiology of …

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Klf2 endothelial cell

Tumor Necrosis Factor Alpha-Mediated Reduction of KLF2 Is …

WebKLF2orchestrates vascular homeostasis and serves as a key molecular switch between proinflammatory atheroprone and quiescent atheroresistant endothelial phenotype. This characteristic is attributed to its ability to activate atheroprotective and inhibit atherogenic endothelial transcription programs. WebInterestingly, KLF2 inhibits endothelial cell activation by diverse proinflammatory stimuli, including interleukin (IL)-1β, tumor necrosis factor (TNF)α, lipopolysaccharide, and …

Klf2 endothelial cell

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WebOur studies suggest that endothelial Klf2 is expressed in response to fluid shear forces and is required for vascular hemodynamic regulation during development, but they do not … WebIn the procession of endothelial growth, KLF2 can act with ERG to activate the expression of Flk1 which is the receptor of vascular endothelial growth factor ... Similarly, miR-25–3p targets and represses the expression of KLF2 and KLF4 in endothelial cells, inhibiting the production of ZO-1, occluding, and Claudin5, ...

WebApr 13, 2024 · For instance, activation of the MEK5/ERK5/KLF2 pathway by fluid shear stress in endothelial cells has recently been shown to require mROS production (Coon et al., J Cell Biol (2024) 221 (7): e202409144). By contrast, Abe’s group observed that H2O2 stimulation could enhance ERK5 phosphorylation but inhibited ERK5-mediated gene expression (e.g ... WebWe recently reported the observation that KLF2 is a potent inducer of endothelial nitric oxide synthase, a key regulator of vessel biology. 16 To gain greater insight into additional …

WebFeb 2, 2024 · KLF2 and KLF4 control endothelial identity and vascular integrity - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. sharing sensitive information, make sure you’re on a federal

Lung buds removed from KLF2-deficient mouse embryos and cultured from normal tracheobronchial trees. In order to circumvent embryonic lethality usually observed in KLF2-deficient embryos, KLF2 homozygous null mouse embryonic stem cells were constructed and used to produce chimeric animals. These KLF2-deficient embryonic stem cells contribute significantly to development of skeletal muscle, spleen, heart, liver, kidney, stomach, brain, uterus, testis, and …

WebLung Kruppel-like factor/KLF2 is highly expressed in the vascular endothelium (17). Systemic knockout of KLF2 results in embryonic death and abnormal vessel formation (17, 18). However, our understanding of the function and targets of KLF2 in endothelial biology have been lacking to date. We recently identified KLF2 as a novel transcriptional reg- buprenorphine sl tablet splitWebMay 5, 2004 · Overexpression of KLF2 in umbilical vein endothelial cells robustly induced endothelial nitric oxide synthase expression and total enzymatic activity. In addition, KLF2 … buprenorphine shows positive on a drug testWebJan 1, 2024 · Background & Aims. The transcription factor Krüppel-like factor 2 (KLF2), inducible by simvastatin, confers endothelial vasoprotection. Considering recent data … buprenorphine sr-lab