Klf2 hippo
WebFeb 4, 2016 · Zfp36 is an RNA-binding protein that promotes degradation of mRNAs of several components of the AP1 family, 54,72 whereas Klf2 is a TF implicated in both proliferation and quiescence of lymphoid cells. 73 To confirm a repressor role of Klf2 at the pre-BCR checkpoint, we identified direct target genes of Klf2 by analysis of pro-/pre-B … WebApr 25, 2006 · Mechanistically, KLF2 inhibits the transcriptional activity of both NF-κB and activator protein 1, in part by means of recruitment of transcriptional coactivator …
Klf2 hippo
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WebApr 25, 2006 · The mechanisms regulating activation of monocytes remain incompletely understood. Herein we provide evidence that Kruppel-like factor 2 (KLF2) inhibits proinflammatory activation of monocytes. In vitro, KLF2 expression in monocytes is reduced by cytokine activation or differentiation. Consistent with this observation, KLF2 expression … WebJun 5, 2014 · Highlights. •. Klf2 is critical for ground state pluripotency. •. Klf2 is negatively regulated by Mek/Erk signaling at the posttranslational level. •. Erk2 directly interacts with and phosphorylates Klf2. •. Overexpression of Klf2 can replace Mek inhibition during ground state pluripotency.
WebMar 27, 2024 · KLF2-V5– or mock-transduced HUVECs were washed twice with PBS before cross-linking with 37% formaldehyde for 10 min at room temperature. Cells were lysed with cytoplasmic lysis buffer, followed by nuclear lysis buffer. Extracts of nuclei were sonified using Bransons Diagenode for 45 cycles on high amplitude (30 s on followed by 30 s off) … WebJun 1, 2006 · The flow-responsive transcription factor KLF2 is acquiring a leading role in the regulation of endothelial cell gene expression. A genome-wide microarray expression profiling is described employing lentivirus-mediated, 7-day overexpression of human KLF2 at levels observed under prolonged flow.
WebNov 18, 2024 · KLF2 regulates metaflammation transcription in macrophages RNA-sequencing of bone marrow-derived macrophages (BMDMs) isolated from myeloid … WebKLF2 (kruppel-like factor 2 [lung]) regulates osteoclastogenesis by modulating autophagy Macroautophagy/autophagy is involved in myeloid cellular repair, destruction, and osteoclast differentiation; conversely, KLF2 (kruppel-like factor 2 [lung]) regulates myeloid cell activation and differentiation.
WebJul 31, 2009 · KLF2 expression was induced acutely by hypoxia in endothelial cells. Adenoviral overexpression of KLF2 inhibited hypoxia-induced expression of HIF-1alpha and its target genes such as interleukin 8, angiopoietin-2, and vascular endothelial growth factor in endothelial cells.
To investigate the effects of shear flow on YAP activity in endothelial cell, we used a HUVEC cell line which is reliable and widely used in studying the mechanism of arteriosclerosis, because HUVEC cells are characterized by unlimited growth while maintaining endothelial cell characteristics16. HUVECs were … See more As UF downregulated the total abundance of YAP, we subsequently wanted to ascertain how YAP is inactivated under UF. A previous study revealed that YAP can be inactivated by … See more We subsequently examined autophagy levels in HUVECs by monitoring LC3 puncta with immunofluorescence. LC3 staining was relatively weaker in CD31-positive ECs treated with DF compared with those exposed to … See more Post-translational modifications, such as phosphorylation, acetylation, and ubiquitination, define the transcriptional activation of YAP. In … See more To ascertain whether autophagy inhibits the development of atherosclerosis by manipulating YAP, we treated HUVECs with a … See more things for kids to do in hilton headWebEPO promotes VEGE and its receptor (KDR) expression and participates in the regulation of HIF-1α and eNOS protein expression through the activation of AMPK-KLF2 signaling pathways to promote new vascular development after cerebral ischemia. things for kids to do in helenWebMar 21, 2024 · KLF2 (KLF Transcription Factor 2) is a Protein Coding gene. Diseases associated with KLF2 include Cerebral Cavernous Malformations and Spleen Cancer . Among its related pathways are White fat cell differentiation and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers . sake bite beauty swatch